Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels

• 作者: Dengtang Liu Tong Wang Xiaoyun Guo Xingguang Luo
• 来源期刊: 综合精神医学(英文)
• 学科: 医学
• 关键词: AETIOLOGY of BIPOLAR DISORDER CONTRIBUTION calcium CHANNELS
• 年，卷（期）: 2019,（3）
• 页码范围: 152-154
• 页数: 3页
• 分类号: R

摘要

LTCCS ARE IMPLICATED IN THE PATHOLOGY OF BIPOLAR DISORDER Bipolar disorder (BPD) is a common mental illness with significant morbidity and mortality.1 Although evidence have suggested changes in oxidative stress, dopamine and inflammation in BPD, it is hard to define the aetiological mechanism of BPD clearly. Recently, some but not all candidate gene association studies, family-based association studies, linkage studies, genome-wide association studies (GWASs) and meta-analyses showed that mutation of L-type voltage-gated calcium chan? nels (LTCCs) gene CACNAlCis implicated in the mechanism of BPD.'-8 These findings support the possibility that BPD might have calcium channelopathy.