With the support by the National Natural Science Foundation of China,the research team directed by Prof.Pan Xin (潘欣)and Prof.Zhang XueMin (张学敏) at the State Key Laboratory of Toxicology and Medical Countermeasures,Institute of Pharmacology and Toxicology,National Center of Biomedical Analysis,recently reported that a mitochondrial Ca2+ transient is essential for mitotic progression,which was published as a cover story in Nature Cell Biology (2019,21:476-486).