Ginkgo biloba extracts prevent aortic rupture in angiotensin Ⅱ-infused hypercholesterolemic mice

• 来源期刊: 中国药理学报（英文版）
• 关键词: abdominal aortic aneurysm angiotensin hypercholesterolemia ginkgo biloba extracts flavonoids ginkgolides
• 年，卷（期）: 2019,（2）
• 页码范围: 192-198
• 页数: 7页
• 语种: 英文

摘要

Abdominal aortic aneurysms (AAAs) are a chronic vascular disease characterized by pathological luminal dilation.Aortic rupture is the fatal consequence of AAAs.Ginkgo biloba extracts (GBEs),a natural herb extract widely used as food supplements,drugs,and cosmetics,has been reported to suppress development of calcium chloride-induced AAAs in mice.Calcium chloride-induced AAAs do not rupture,while angiotensin Ⅱ (Angll)-induced AAAs in mice have high rate of aortic rupture,implicating potentially different mechanisms from calcium chloride-induced AAAs.This study aimed to determine whether GBE would improve aortic dilation and rupture rate of Angll-induced AAAs.Male apolipoprotein E (apoE)-/-mice were infused with Angll and administered either GBE or its major active ingredients,flavonoids and ginkgolides,individually or in combination.To determine the effects of GBE in mice with established AAAs,male apoE-/-mice were firstly infused with Angll for 28 days to develop AAAs,and then administered either GBE or vehicle in mice with established AAAs,which were continuously infused with Angll for another 56 days.GBE,but not the two major active components separately or synergistically,prevented aortic rupture,but not aortic dilation.The protection of GBE from aortic rupture was independent of systolic blood pressure,lipid,and inflammation.GBE also did not attenuate either aortic rupture or progressive aortic dilation in mice with established AAAs.GBE did not reduce the atherosclerotic lesion areas,either.In conclusion,GBE prevents aortic rupture in Angll-infused hypercholesterolemic mice,but only in the early phase of the disease development.