Single-molecule DNA logic nanomachines based on origami

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（4）
• 页码范围: 407-408
• 页数: 2页
• 语种: 英文

摘要

Nowadays,it is a truism that chemists,bioengineers and others must be schooled in cell and molecular biology,including knowledge of the cellular,elemental and molecular building blocks of living systems.Inspired by exquisite and efficient biomolecular machines in living cells,such as AT-Pases that catalyze the decomposition of ATP into ADP and free phosphate ion,researchers representing multiple disciplines are actively engaged in developing artificial nanostructures with well-defined geometry and nanoscale addressability.A successful outcome of these studies could lead to the development and clinical application of smart molecular machines for the drug delivery of theranostics in vivo.While a macromolecular machine can perform DNA replication or ATP synthesis [1],molecular machines consist of "any discrete number of molecular components that produce quasi-mechanical movements as well as in response to specific stimuli" [2,3].The latter might include such devices as actuators and switches,based on conformational changes in biomolecules,as well as biomolecular walkers and motors,which change their spatial position and also carry cargos across the cell membrane.However,while biomolecular machines are able to "make decisions" with spatiotemporal ordering at the molecular level based on intrinsic programmability,the coupling of molecular action to simple decision-making processes is extremely difficult to accomplish in artificial systems.