Clinical and microstructural changes with different iontophoresis-assisted corneal cross-linking methods for keratoconus

• 作者: Fen Chen Kai Liao Min Hu Pei Li Peng Song Qing-Yan Zeng
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: KERATOCONUS transepithelial CORNEAL CROSSLINKING IONTOPHORESIS anterior STROMAL KERATOCYTE subbasal nerve density
• 年，卷（期）: 2019,（2）
• 页码范围: 219-225
• 页数: 7页
• 分类号: R

摘要

AIM:To compare the clinical and microstructural changes induced by different transepithelial iontophoresis-assisted corneal cross-linking(I-CXL) methods for keratoconus. METHODS:A total of 42 eyes of 42 patients with progressive keratoconus were divided into two groups. Group A received I-CXL for 5min, while group B received I-CXL for 10 min. Visual acuity, optical coherence tomography(OCT), specular microscopy and confocal microscopy were evaluated preoperatively and at 1, 3, 6, and 12 mo postoperatively. RESULTS:Twelve months after the operation, uncorrected visual acuity(UCVA) and corrected distance visual acuity(CDVA) were improved in both groups, with a better outcome in the I-CXL 10 min group(P=0.025, 0.021, respectively). Kmax values decreased by 0.94±3.00 D in the I-CXL 10 min group(P=0.033) but increased by 1.87±3.29 D in the I-CXL 5min group(P=0.012). OCT scans showed that the demarcation line was most visible and substantially deeper in the I-CXL 10 min group. Confocal microscopy showed greater anterior stromal keratocyte decreases in the I-CXL 10 min group than in the I-CXL 5min group at 3 and 6mo postoperatively(P<0.001);however, anterior stromal keratocytes and subbasal nerve density were not significantly different between the two groups at 12 mo postoperatively.