Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

• 来源期刊: 药学学报（英文版）
• 关键词: Fluorescent probes 10-Hydroxyevodiamine Anticancer mechanisms Autophagy Apoptosis
• 年，卷（期）: 2019,（1）
• 页码范围: 144-156
• 页数: 13页
• 语种: 英文

摘要

Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents.However,the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms.To tackle this obstacle,herein,novel fluorescent probes were designed to elucidate the antimmor mode of action of 10-hydroxyevodiamine.This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms.