Electronic health records (EHR) is a documentation tool that improves the quality and safety of patient care.However, certain challenges are experienced by nurses.This Special Focus Issue aims to collect novel nursing informatics research and case report that highlight the challenges of utilizing electronic health records, specifically EHR relevant nursing practices, interventions, evaluations,policies, theories, etc.This special issue welcomes original research papers, perspectives, conceptual papers, case reports, systematic review, and scoping review articles that address a range of topics including, but are not limited to, the following areas: