The relationship between human papillomavirus and penile cancer over the past decade: a systematic review and meta-analysis

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2019,（4）
• 页码范围: 375-380
• 页数: 6页
• 语种: 英文
• DOI: 10.4103/aja.aja_39_19

摘要

Human papillomavirus (HPV) infection appears to play an important role in the development of penile cancer (PeCa),but their relationship remains unclear.Therefore,we performed a systematic review and meta-analysis to elucidate their relationship.We systematically searched Embase,PubMed,Cochrane Library,and Web of Science for case-control studies and cross-sectional studies using polymerase chain reaction (PCR) technology on formalin-fixed paraffin-embedded (FFPE) or paraffin-embedded (PE)PeCa tissues to detect HPV (published between January 1,2007,and December 29,2017;no language restrictions).Twenty-two studies were identified,and 1664 cases were available for analysis.The combined HPV infectious risk of PeCa is 51.0％ (95％ confidence interval [CI]:43.0％-60.0％).The three most common subtypes of HPV were HPV16 (28.5％),HPV18 (2.3％),and HPV6 (2.3％).The virus was relevantly associated with basaloid (85.5％,95％ CI:77.2％-93.8％) and warty (50.0％,95％ CI:35.2％-64.8％) carcinomas.The invasiveness of PeCa was not associated with HPV (x2 =0.181,df =1,P＜ 0.671).HPV infection in PeCa tended to be moderately differentiated (54.4％,95％ CI:47.7％-61.1％).This study found that almost half of PeCa patients are associated with HPV.The most commonly associated genotype is HPV16,but several other genotypes were also detected.In addition to types 6 and 11,other single low-risk HPV infections have been found to contribute to PeCa to a lesser degree.HPV-positive tumors tend to exhibit warty and/or basaloid features,corresponding to a moderate histological grade.The role of HPV in PeCa should be revisited to provide evidence for the development of PeCa in the presence of HPV infection.