The Prognostic Significance of Pre and Post Treatment Neutrophil to Lymphocyte Ratio in Breast Cancer Patients

• 作者: Amen H. Zaky Ashraf Zeidan Asmaa M. Zahran Hanan A. Eltyb Nehal A. Rayan
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: BREAST Cancer NLR DFS OS
• 年，卷（期）: azzlyw_2019,（7）
• 页码范围: 525-536
• 页数: 12页
• 分类号: R73

摘要

Background: The neutrophil/lymphocyte ratio (NLR) has been reported to reflect systemic inflammation and independent prognostic significance in different types of cancer. In present study, we analyzed the association between NLR and clinicopathologic features and verified the significance of NLR as a prognostic factor for patients with breast cancer. Patients and Methods: A total of 388 patients with stage I - III breast cancer were retrospectively recruited into this study. Associations with clinicopathologic factors and NLR were assessed;disease-free survival and overall survival were estimated. Results: There was no significant association between NLR and clinicopathologic factors. Patients with low pre/post-treatment NLR had longer OS. Conclusion: A high pre/postoperative NLR may be considered an important factor for predicting poor prognosis in non-metastatic breast cancer patients.