Toward the identification and role of structural variations during dog domestication

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 123-124
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/nsr/nwy086

摘要

To date,we know little about the genetic diversity and development mechanisms that,through the process of domestication,have made the modern dog emerge.Following the processes of domestication and a phase of intense artificial selection,dogs became our auxiliaries for hunting,guarding and finally our best friends.The range of phenotypic diversity in dogs today greatly exceeds that of its ancestors,the wolves,making dogs the most morphologically diverse species of terrestrial mammals [1].To advance these domestication research questions,studies are now focusing on differences in the content,organization and structure of the genome,called structural variations (SV),as a major source of genetic and phenotypic diversity.In addition,SVs have also emerged to provide an important substrate for evolutionary innovations.SVs have marked genomic effects,altering gene expression,affecting gene dosing,losing regulatory elements,unmasking regulatory polymorphisms and affecting the evolution of new genes.