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BACKGROUND Triclosan-coated vicryl plus suture(Ethicon, Inc.) was developed to reduce microbial colonisation during surgical procedures. However, its effect on wound healing and surgical site infections remain unclear after hip and knee arthroplasty surgery.AIM To determine the effect of triclosan-coated sutures(TCS) vs non-coated sutures on wound healing, following primary hip and knee arthroplasties.METHODS A single-centred, double-blind randomised controlled trial(RCT) was undertaken. We randomly allocated patients to receive either the triclosan-coated sutures(TCS vicryl plus) or non-coated sutures(NCS vicryl) during the closure of unilateral primary hip and knee arthroplasties. We utilised the ASEPSIS wound scoring system to evaluate wound healing for the first 6 weeks post-operatively.RESULTS One hundred and fifty patients undergoing primary total hip or knee arthroplasty over a one-year period were included. Eighty-one were randomised to the TCS group and 69 to the NCS group. Despite no statistically significant difference in the ASEPSIS scores among the study groups(P = 0.75), sensitivity analysis using the Mann Whitney test(P = 0.036) as well as assessment of the wound complications at 6 weeks follow up, demonstrated significantly higher wound complication rates in the TCS group(8 vs 1, P = 0.03).CONCLUSION No clear advantage was demonstrated for using the TCS. However, larger multicentred RCTs are required to validate their use in hip and knee arthroplasty surgery.
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篇名 Randomised controlled trial of triclosan coated vs uncoated sutures in primary hip and knee arthroplasty
来源期刊 世界骨科杂志(英文版) 学科 医学
关键词 TRICLOSAN Hip KNEE Replacement ARTHROPLASTY Wound HEALING COMPLICATIONS
年,卷(期) 2019,(7) 所属期刊栏目
研究方向 页码范围 268-277
页数 10页 分类号 R687.4
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节点文献
TRICLOSAN
Hip
KNEE
Replacement
ARTHROPLASTY
Wound
HEALING
COMPLICATIONS
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研究来源
研究分支
研究去脉
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相关学者/机构
期刊影响力
世界骨科杂志:英文版
月刊
2218-5836
北京市朝阳区东四环中路62号楼远洋国际中
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404
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