Based on his teaching experiences and clinical observations at Mental Health Centers,the author presents shortly the results of his clinical researches and will discuss on“psychopathological effects of depression and anxiety on insomnia”and very summarily on the treatment.The studies and lectures at the University Hospitals:Ir.,IL,USA and France,especially during the last decades,have enriched this study research.The experiences and researches have clearly shown that depression and anxiety resulting from catastrophic life events,exert pathological effects not only on cognitive and cardiovascular system but have also psychopathological effects on internal organs such as pineal gland with its melatonin secretion which is considered as stimulator system to regulate the rhythm of wake-sleep.Major depression and anxiety,when accumulating and occurring together,can not only perturb the circadian rhythm,which leads to insomnia,but also in some extreme situations as observed,can engender behavior and personality disorders that in some cases lead to suicide.Concerning the treatments in some cases in which the parents in major depression are suffering from the death of children,in parallel of pharmacotherapy,or other family care and treatments,the author proposed“Child Replacement”plan in period of mourning.Among the various drugs effective for treatment of insomnia we indicate:Agomelatine-Mianserine-Amitriptyline-Doxepin-Fluoxetine,well interesting to be noted.