SCNN1B and CA 12 play vital roles in occurrence of congenital bilateral absence of vas deferens(CBAVD)

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2019,（5）
• 页码范围: 525-527
• 页数: 3页
• 语种: 英文
• DOI: 10.4103/aja.aja_112_18

摘要

Dear Editor, Congenital bilateral absence of the vas deferens (CBAVD),a complete or partial defect of the Wolffian duct derivatives,is found in ＞25％ of men with obstructive azoospermia (OA),but the underlying pathological mechanism remains poorly understood.Previous research has shown that the most common disease associated with CBAVD is cystic fibrosis (CF),the predominant manifestations of which include progressive lung disease,pancreatic dysfunction,elevated sweat chloride electrolyte,meconium ileus,and male infertility.