Expression of adipokines in seminal fluid of men of normal weight
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摘要:
Dear Editor,
Infertility affects about 48.5 million couples worldwide,and a male disorder is estimated to be a causative or contributing factor in 20%-50% of cases.1 Notably,increasing data support the view that obese men are at higher risk offertility disorders.2 As is known,obesity is defined by an excess of white adipose tissue,currently recognized as being able to secrete many endocrinologically active molecules called adipokines?Their involvement in animal and human reproduction is recognized.4 Indeed,in rodents,the removal of epididymal adipose tissue decreases spermatogenesis and males lacking adipokines or their receptors have reduced fertility.3 Concerning humans,mature spermatozoa present leptin receptors on their surface,5 and recently,adiponectin,resistin,chemerin,visfatin,and vaspin have been identified in seminal fluid (SF).