Mineral iron based self-assembling: bridging the small molecular drugs and transformative application

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2019,（4）
• 页码范围: 216-218
• 页数: 3页
• 语种: 英文

摘要

The nanoparticle-based treatment and diagnosis of cancer remain challenging in clinical translation,mainly due to the hurdles that can be associated with the development of targeted delivery,biological side effects,poor drug loading efficiency (DLE),and instability and so on [1,2].For example,one of the major challenges for targeted drug delivery to tumor tissues would be the biological barriers encountered during the process,including hemorheoiogical flow limitations,endothelial association/extravasation and impaired delivery across tumor cell membranes and tissues [3].In addition to overcome these biological barriers,the physiochemical properties,such as size,charge,morphology and surface chemistry,have also been emphasized in the biostability and biodistribution of drugs [4].To address these issues,a number of multifunctional nanoparticle systems have been developed to enhance the delivery efficiency,such as cell surface cascaded landing location for active tumor targeting [5],and nanoscopic drug carriers (e.g.,liposomes,nanoemulsions,nanoparticles or micelles) [6].With the help of these delivery systems,functional cargos can be delivered to the tumor sites via physical entrapment or chemical conjugation [2,7].However,most of these drug delivery systems or materials have little access for applying in clinical practice,especially the biosafety concerns of the carriers,which may result in the side-effects caused by immune rejection and serious inflammation to kidneys and other organs during degradation,metabolism,and excretion.