One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（2）
• 页码范围: 235-238
• 页数: 4页
• 语种: 英文
• DOI: 10.1007/s40242-019-8277-4

摘要

A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde,malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO.This protocol is featured by mild reaction conditions,simple operation and environmental acceptability.