Resveratrol attenuates metabolic, sperm, and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2019,（2）
• 页码范围: 201-207
• 页数: 7页
• 语种: 英文

摘要

High-fat diets affect male reproduction and sexual function.Therefore,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria diet.Male Wistar rats were divided at weaning into control (C,n =20) and cafeteria (CAF,n =16) groups.At 3 months,half of them were given daily supplementations of resveratrol (C-R,n =10;CAF-R,n =8) at a dosage of 30 mg kg-1 body mass for 2 months.Animals were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further analysis.Data were analyzed by one-way ANOVA,and P ＜ 0.05 was considered statistically significant.The CAF diet promoted hyperglycemia (P＜ 0.0001),and treatment with resveratrol reversed this condition (P＜ 0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters (P＜ 0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group (P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C group.However,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group (P =0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis.