Persistent Zika Virus Infection Associated with Early Fetal Demise: A Case Report

• 作者: Dana Meaney-Delman Dania M. Rodriguez Gabriela Paz-Bailey Janice Pérez-Padilla Joy Gary Julu Bhatnagar Kate Doyle Luisa Alvarado Nicole M. Pérez-Rodriguez Sara Montalvo Tyler M. Sharp
• 来源期刊: 妇产科期刊(英文)
• 学科: 医学
• 关键词: Zika PREGNANCY OUTCOMES ZIKV PERSISTENCE
• 年，卷（期）: 2019,（5）
• 页码范围: 698-706
• 页数: 9页
• 分类号: R73

摘要

Background: Infection with Zika virus (ZIKV) during pregnancy is known to cause birth defects and could also be linked to pregnancy loss. Case: A pregnant woman in Puerto Rico contracted ZIKV at 16 weeks gestation. ZIKV RNA persisted in serum from her initial test at 16 weeks through 24 weeks gestation, when fetal demise occurred, and was detected in placental tissue. Conclusion: Prolonged detection of ZIKV RNA in maternal serum was associated with ZIKV RNA detection in the placenta of a patient who experienced fetal demise. While detection of placenta ZIKV RNA does not establish that ZIKV conclusively caused the demise, these findings support emerging evidence that the placenta may serve as a reservoir for ZIKV, which may be associated with prolonged detection of ZIKV RNA in serum.