MYC retards cancer cell migration through suppressing fibronectin expression

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2019,（11）
• 页码范围: 715-717
• 页数: 3页
• 语种: 英文

摘要

The oncoprotein MYC is a transcription factor that regulates a range of genes involved in various biological processes including cell cycle arrest,cell proliferation,metabolism,protein synthesis and genomic instability.Recently,MYC has been shown playing a role in regulating cancer cell metastasis,while outcomes of this regulation remain controversial.In some breast tumors,MYC accelerates metastasis by elevating miR-9 miRNA expression [1].However,under certain circumstance,MYC activation may have an opposite function in suppressing cell motility and impairing cancer invasion [2-4].Intriguingly,through direct suppressing expressions of αv and β3 integrin subunits,MYC impedes breast cancer cell metastasis [3].Moreover,MYC blocks JNK signaling and consequently causes reduced tumor cell migration [5].Therefore,the role of MYC in cell migration is largely unknown and needs further investigation.