Enantioselective Resolution of (±)-1-Phenylethyl Acetate by Using the Whole Cells of Deep-sea Bacterium Bacillus sp.DL-2

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（5）
• 页码范围: 792-798
• 页数: 7页
• 语种: 英文
• DOI: 10.1007/s40242-019-9126-1

摘要

Bacillus sp.DL-2 was isolated from the deep sea of the Western Pacific and further utilized as novel biocatalysts to efficiently asymmetrically hydrolyze (±)-l-phenylethyl acetate.After the optimization of hydrolytic reactions,chiral chemicals (R)-l-phenylethanol and (S)-l-phenylethyl acetate were obtained with high optical purities (96％ and 99.8％,respectively).Our research is about the asymmeric hydrolysis of (±)-l-phenylethyl acetate using whole-cell biocatalysts.In addition,the optical purity of (S)-l-phenylethyl acetate generated through the kinetic resolution of (±)-l-phenylethyl acetate using the whole-cells of Bacillus sp.DL-2 was the highest report so far.Using the whole cells of deep sea bacterium Bacillus sp.DL-2 as the biocatalysts is an environmentally friendly method and will play critical roles in industrial asymumetric synthesis.