Editor's notes

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 109
• 页数: 1页
• 语种: 英文
• DOI: 10.1093/nsr/nwz011

摘要

The two research articles from the Institute of Neuroscience of Chinese Academy of Sciences represent the new format for publishing significant findings as stated in an editorial of National Science Review [1]. The first article describes the generation of a group of gene-edited macaque monkeys by CRISPR/Cas9 editing of monkey embryos that deleted the expression of a core circadian regulatory transcription factor BMAL1.These monkeys exhibited the loss of sleep and psychosis-like phenotypes.The second article describes the cloning of a group of monkeys by somatic cell nuclear transfer (SCNT),using a juvenile gene-edited monkey from the first study that exhibits the most severe circadian-disorder phenotypes.These two pieces together demonstrate that a population of customized gene-edited macaque monkeys with uniform genetic background will soon be available for biomedical research.