Synthesis of A-B-C-ring Tricyclic Core of iso-Merrilactone A

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（5）
• 页码范围: 817-822
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/S40242-019-9064-y

摘要

A desymmetrization approach for the synthesis of the A-B-C tricycle intermediate of iso-merrilactone A was described.The key steps of this synthesis to efficiently access the tetracyclic Illicium sesquiterpenes core included an intramolecular aldol cyclization and an oxidative lactonization reaction.A novel Au catalyzed hydrolytic cyclorearrangement cascade reaction was explored in the initial stage.