Gain-of-function mutant p53: history and speculation

• 作者: Carol Prives Jill Bargonetti
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2019,（7）
• 页码范围: 605-609
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz067

摘要

Arnold Levine and the history of p53 The history of the p53 tumor suppressor (and of the p53 field of research) is quite extraordinary.First discovered in the late 1970s as a protein associated with the SV40 large tumor antigen (and also as a protein that was found in some nonvirally transformed cells), p53 was commonly viewed as a facilitator of oncogenic cell transformation (for an excellent review of the early history of p53 see Levine and Oren, 2009).It took nearly 10 years for the cancer research field to realize that wild-type p53 is a tumorsuppressor protein.