Restoring p53 in cancer: the promises and the challenges

• 作者: Guillermina Lozano
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2019,（7）
• 页码范围: 615-619
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz063

摘要

A tribute to Dr Arnold J.Levine This perspective was written in celebration of DrArnold J.Levine's 80th birthday.I chose to write this prospective about restoration of p53 activity in tumors for two reasons: Arnie (as we all know him) has become interested in restoring p53 activity in tumor cells and such a review did not exist.Arnie was also my postdoctoral advisor and writing this perspective is just a small tribute for the huge impact he has had on my research career (and that of many others), from supporting me when I left his laboratory for a faculty position before I had even published a paper, to serving as a sounding board for numerous ideas.Arnie is an amazingthinker.