Arnie Levine and the MDM2-p53 discovery: a postdoctoral fellow's perspective

• 作者: Gerard P.Zambetti
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2019,（7）
• 页码范围: 620-623
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz073

摘要

It was early 1990 that we had gathered at Arnie Levine's home for dinner to celebrate the transition of several postdoctoral fellows to faculty positions in academia.As a new postdoctoral fellow in his lab, I was thrilled to have the opportunity to spend some personal time with Arnie.We were discussing the paradigm shift made by his group a year earlier that p53 is a tumour suppressor (Finlay et al.,1989) and not an oncogene, as originally thought for a decade after its original discovery (Lane and Crawford, 1979;Linzer and Levine, 1979).Paraphrasing Arnie's comment about this landmark discovery, he said that it was fun, a really big wave to ride, and not to worry as there will be more to come.Unknowingly at the time,that prediction led to the identification of Mdm2 as a negative regulator of p53.