pH-Sensitive assembly/disassembly gold nanoparticles with the potential of tumor diagnosis and treatment

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 105-117
• 页数: 13页
• 语种: 英文

摘要

Due to the ability to combine the separately unique characteristics of assembled and disassembled nanoparticles (NPs),the stimuli-responsive self-assembly of NPs has attracted considerable interest in functional material applications especially biomaterials.Here we demonstrate a facile and versatile approach to regulate the self-assembly process and transition pH ofAu NPs by fine-tuning the co-modified pH-responsive compounds and poly(ethylene glycol) (PEG).Importantly the transition pH (ApH=0.4) of the system can be predetermined in the range of 8.2-5.8 (assembled to disassembled) and 8.2-4.2 (disassembled to assembled),which ideally covers the pH of normal tissue,tumor tissue milieu and organelles.The results of fluorescence imaging,Raman spectroscopy and photothermal conversion of the stimuli-responsive Au NPs shows the potential application for tumor specificity theranostics.In a nutshell this study provides a useful toolkit to design tumor-activatable self-assembled NPs with high specificity and universality.