Mathematics of microRNAs: stabilizing gene regulatory networks

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（6）
• 页码范围: 1189-1190
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/nsr/nwz112

摘要

MicroRNAs (miRNAs) are fascinating in their versatility.Animal cells express hundreds of distinct microRNAs,and each microRNA can regulate hundreds of distinct mRNA targets.Therefore,in aggregate,the microRNA compliment of a cell can exert pervasive effects on gene expression.Individual microRNAs can also be potent determinants ofphenotype:The first microRNAs identified by genetics in nematodes [1,2] and Drosophila [3] function as master regulators controlling genetic switches between cell fates,largely by repressing translation of the mRNA of a single target-for example,lin-41 in the case of the let-7 microRNA [4],or Hid in the case of bantam [3].