The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2019,（2）
• 页码范围: 362-364
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, Essential tremor (ET) is one of the most common movement disorders of unknown etiology [1,2],having an overall prevalence of 4％ in the general population [2].The age at onset has been reported to be between 15 years and 20 years,and penetrance to be complete at between 50 years and 70 years.It seems to be a progressive neurological disorder,and can lead to substantial disability in some patients.Although it presents some degree of clinical variability,it occurs in sporadic (SET) and familial (FET) forms with heterogeneity of expression between and within families [3].ET is characterized essentially by a postural and kinetic tremor most often affecting the arms,but it can also affect other parts of the body [4].Nonetheless,familial expression of ET has been linked to some loci [5-7].