Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（5）
• 页码范围: 649-652
• 页数: 4页
• 语种: 英文

摘要

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3-substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized.A broad range of the 3,Y-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields (up to 96％) with high diastereoselectivities (up to ＞19:1 dr) and enantioselectivities (up to 96:4 er).