Improved Synthesis of Icaritin and Total Synthesis of β-Anhydroicaritin

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（4）
• 页码范围: 616-620
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s40242-019-9012-x

摘要

Natural products icaritin and β-anhydroicaritin with P-glycoprotein(P-gp) inhibitory activities were efficiently synthesized in nine steps from commercially available phloroglucinol.A modified Algar-Flyrm-Oyamada cyclization and relay Claisen-Cope rearrangement were employed in this concise route.Our synthesis offers opportunities to synthesize various icariin analogues for biological and pharmacological investigations.