Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 80-85
• 页数: 6页
• 语种: 英文

摘要

Lycopene is a natural compound that alleviates oxidative stress and inflammation,exerting therapeutic effects in a number of cancers.The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer.Cell viability assays indicated the dose-and time-dependent toxicity of lycopene in prostate cancer cells.Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene.The levels of inflammatory factors,including interleukin-1 (IL1),IL6,IL8,and tumor necrosis factor-α (TNF-α),in lycopene-treated cells were also reduced by lycopene treatment.With the increasing dose of lycopene,the survival of mice bearing prostate cancer xenografts was significantly improved (P ＜ 0.01),and the tumor burden was significantly reduced (P ＜ 0.01).Our results indicate that lycopene is a promising chemotherapy drug,which inhibits prostate cancer progression by suppressing the inflammatory response.