In vivo fluorescence imaging in the second near-infrared (NIR-Ⅱ) window (1000-1700 nm) has been emerging as a new powerful imaging technique and demonstrated tremendous potential in life sciences and biomedical applications,given its advances in reducing photon scattering,light absorption,and autofluorescence [1,2].In particular,extensive efforts have been made to produce various NIR-Ⅱ probes with different emission wavelengths for multiplexing purposes,as practical applications typically require concurrent detection of multiple analytes.