Selective N-Alkylation of 2-Amino-4H-chromene-3-carbonitrile Derivatives with Alcohols Catalyzed by AlCl3 Under the Assistance of CH3COOH

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（6）
• 页码范围: 997-1001
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s40242-019-9248-5

摘要

A highly efficient and selective N-alkylation reaction of 2-amino-4H-chromene-3-carbonitrile derivatives using various alcohols as alkylation agent were developed in the presence of AlC13 as a catalyst as well as CH3COOH as an additive,in which the cyano group kept inert and the amino group was alkylated in high yields.All the target products were characterized and determined by infrared(IR),1H NMR,13C NMR,and HRMS.And the X-ray structure of product 3ab was obtained.A bimolecular reaction mechanism catalyzed by AlCl3 was proposed under the assistance of CH3COOH.