K3PO4-promoted Cyclopropanation of Electron-deficient Alkenes with 2-Bromo-1,3-propanedione Compounds

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（6）
• 页码范围: 1002-1007
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s40242-019-9137-y

摘要

An easy and efficient method for the synthesis of multisubstituted cyclopropane derivatives from electrondeficicent alkenes with 2-bromo-l,3-propanedione compounds was described.For this method,ethyl a-cyanocinnamate derivatives 1 and β,β-dicyanostyrene derivatives 4 can all smoothly react with 2-bromo-l,3-propanedione compounds 2 to afford the corresponding multisubstituted cyclopropane derivatives 3 and 5 in good to excellent yields(up to 100％) promoted by anhydrous K3PO4 in DMF at room temperature,respectively.A possible mechanism of this reaction was proposed.Structures of all the products were confirmed by 1H NMR,13C NMR and HRMS.