Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2019,（16）
• 页码范围: 1132-1135
• 页数: 4页
• 语种: 英文

摘要

Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor's resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage differentiation potential [1].However,it remains elusive how the CSCs maintain their sternness,thus restricting the development of therapeutic treatments specifically targeting the CSCs.Accumulating evidence has suggested that the genetic and epigenetic changes are responsible for the acquisition of sternness and CSC genesis in hepatocellular carcinoma (HCC) [2],which is a leading cause of cancer-related deaths worldwide [3].In this study,we integrated Hi-C,ATAC-seq and RNA-seq data together with public ChIP-seq sources,to establish the relationship between the epigenetic modulation and transcriptional regulation of the stemness maintenance ofHCC CSCs.This multi-omics method shed lights on the utility of epigenomic profiling to uncover the gene regulation mechanism of CSCs and could efficiently identify promising drug targets for HCC targeted therapy.