Recent advances in radical-mediated [2+2+m] annulation of 1,n-enynes

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（11）
• 页码范围: 1463-1475
• 页数: 13页
• 语种: 英文

摘要

1,n-Enynes are a versatile class of unsaturated hydrocarbons that found broad applications in the synthetic community of natural products,biologically active structures and functional materials.Typical methods for the transformations of 1,n-enynes include the radical-mediated [2+2+m] annulation reaction as they are particularly efficient accesses to functionalized polycyclic compounds.We herein highlighted recent process in the radical-mediated [2+2+m] annulation of 1,n-enynes,including [2+2+1] and [2+2+2] modes,for the construction of five-to six-membered-ring-fused polycyclic scaffolds.Meanwhile,the mechanisms for these transformations were described.