Synthesis of 1,3-benzothiazines by intramolecular dehydrogenative C-S cross-coupling in a flow electrolysis cell

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（11）
• 页码范围: 1501-1503
• 页数: 3页
• 语种: 英文

摘要

DehydrogenativecyclizationofthioamidesisanattractiveapproachforthesynthesisofS-heterocycles.Reportedhereinisanelectrochemical dehydrogenative cyclization reaction of N-benzyl thioamides in a flow electrolysis cell.The continuous-flow electrosynthesis has addressed the limitations associated with previously reported methods for the cyclization of alkylthioamides and provide a transition metal-and oxidizing reagent-free access to various functionalized 1,3-benzothiazines in good yields.