Radical-mediated hydroalkylation of 2-vinylpyrrolidine derivatives: a versatile entry into indolizidine alkaloids

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（11）
• 页码范围: 1504-1506
• 页数: 3页
• 语种: 英文

摘要

A concise route for the preparation of two simple optically pure indolizidin-5-ones has been developed.The key chain elongation process was achieved using a triethylborane/catechol mediated hydroalkylation of Boc-protected 2-vinylpyrrolidines.By using complementary strategies,these two bicyclic lactams can be alkylated with complete control of the stereochemistry at C(5) and their conversion to a variety of indolizidine alkaloids such as coniceine,indolizidine 209D and 167B,5-epi-indolizidine 249A and monomorine has been reported in the literature.