Copper-catalyzed 1,1-difunctionalization of terminal alkynes: a three-component reaction for the construction of vinyl sulfones

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（7）
• 页码范围: 904-908
• 页数: 5页
• 语种: 英文

摘要

A copper-catalyzed 1,1-difunctionalization of terminal alkynes was achieved via a three-component reaction,providing a variety of vinyl sulfones with good yields and excellent chemo-and stereoselectivity.Preliminary mechanistic studies indicated that the reaction probably underwent a Cu-catalyzed formal C-H insertion to produce an allene intermediate,which was then trapped by a sulfonyl anion to give the corresponding product.