Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 21-25
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s40242-019-8273-8

摘要

A new method for the synthesis of 1,4-dihydropyridine(l,4-DHP) calcium channel antagonists felodipine,nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate and ethyl 3-aminoerotonate was developed.Operational simplicity,mild reaction conditions and eco-friendliness are the key features of this protocol.