A Highly Efficient and Recyclable Solid Acid Catalyst for Synthesis of Spiro-oxindole Dihydroquinazolinones Under Ultrasound Irradiation

• 来源期刊: 高等学校化学研究（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 33-40
• 页数: 8页
• 语种: 英文
• DOI: 10.1007/s40242-018-8248-1

摘要

A simple,efficient and green procedure for the synthesis of spiro-oxmdole dihyfroquinazolinones was developed by multi-component condensation of isatoic anhydride,aniline and isatin in the presence of a novel solid acid catalyst under ultrasound irradiation.The present environmentally benign protocol offers several advantages,such as shorter reaction time,a wide range of functional group tolerance,the use of an inexpensive heterogeneous catalyst,and a high yield of products via a simple experimental and work-up procedure.The mesoporous solid acid catalyst was directly prepared from phytic acid by microwave-sulfonation method without template.The phytic acid based solid acid was fully characterized by means of Fourier transform infrared spectroscopy(FTIR),Raman spectroscopy,X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and transmission electron microscopy(TEM).The catalyst can be recovered and reused for at least five runs without significant impact on the product yields.