Reactive uveitis, retinal vasculitis and scleritis as ocular end-stage of Acanthamoeba keratitis: a histological study

• 作者: Berthold Seitz Carmen Hofmann-Rummelt Elena Zemova Fabian Norbert Fries Lei Shi Leonard Holbach Loay Daas Nóra Szentmáry Tobias Hager
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: ACANTHAMOEBA KERATITIS ENUCLEATION UVEITIS retinal VASCULITIS SCLERITIS
• 年，卷（期）: 2019,（12）
• 页码范围: 1966-1971
• 页数: 6页
• 分类号: R73

摘要

We analysed histologically two Acanthamoeba keratitis(AK) eyes with anterior and posterior segment inflammation and blindness. Two enucleated eyes of 2 patients(age 45 and 51y) with AK(PCR of epithelial abrasion positive) were analysed. Histological analysis was performed using hematoxylin-eosin, periodic acid-Schiff and G?m?rimethenamine silver staining. We could not observe Acanthamoeba trophozoites or cysts neither in the cornea nor in other ocular tissues. Meanwhile, we found uveitis, retinal vasculitis and scleritis in these eyes, due to the long-standing, recalcitrant AK. So in this stage of AK, systemic immune suppression may be necessary for a longer time period.