Genome editing in large animals: current status and future prospects

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（3）
• 页码范围: 402-420
• 页数: 19页
• 语种: 英文
• DOI: 10.1093/nsr/nwz013

摘要

Large animals (non-human primates,livestock and dogs) are playing important roles in biomedical research,and large livestock animals serve as important sources of meat and milk.The recently developed programmable DNA nucleases have revolutionized the generation ofgene-modified large animals that are used for biological and biomedical research.In this review,we briefly introduce the recent advances in nudease-meditated gene editing tools,and we outline these editing tools' applications in human disease modeling,regenerative medicine and agriculture.Additionally,we provide perspectives regarding the challenges and prospects of the new genome editing technology.