Regioselective introduction of vinyl trifluoromethylthioether to remote unactivated C(sp3)-H bonds via radical translocation cascade

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（11）
• 页码范围: 1507-1511
• 页数: 5页
• 语种: 英文

摘要

Described herein is an efficient protocol for the regioselective introduction of a vinyl trifluoromethylthioether to remote unactivated C(sp3)-H bonds.The cascade process involves the vinyl radical-mediated 1,5-hydrogen atom transfer (HAT) and remote vinyl migration.During the transformation,inert C-H and C-C bonds are consecutively cleaved under mild conditions.The reaction features good functional group tolerance,broad substrate scope,and high regio-/stereo-selectivity.