Safety & efficacy of single subconjunctival triamcinolone 5 mg depot vs topical loteprednol post cataract surgery: less drop cataract surgery

• 作者: Jagadeesh Kumar Reddy Neeraj Shah Shadab Khan Siddharthan Kuttupalayam Venkata Prabhakar Guduru Vivek Chaitanya
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: intraocular pressure SUBCONJUNCTIVAL TRIAMCINOLONE ACETONIDE PHACOEMULSIFICATION loteprednol cells/flare LESS DROP cataract surgery
• 年，卷（期）: gjykzzywb_2019,（5）
• 页码范围: 774-778
• 页数: 5页
• 分类号: R779.66

摘要

AIM: To do a randomized prospective interventional study for comparing the effects of a single subconjunctival triamcinolone acetonide(SCTA) injection to tapering topical loteprednol in patients undergoing phacoemulsification surgery under topical anesthesia. METHODS: A total of 400 patients were randomized into 2 groups;Group A(200 patients) received 5 mg SCTA at the end of surgery and topical ketorolac tromethamine(0.5%) with ofloxacin(0.3%) combination for 3 wk. Group B(200 patients) received tapering topical loteprednol etabonate(0.5%) along with ofloxacin(0.3%) and ketorolac tromethamine(0.5%) for 3 wk. Outcomes evaluated were intraocular pressure(IOP), anterior chamber cells/flare and macular oedema postoperatively at 1, 6 and 12 wk.RESULTS: Baseline parameters were almost similar in both the groups. No statistical difference was seen between the preoperative and postoperative IOP values for Group A(P=0.82) and Group B(P=0.61) and postoperative IOP values in between both groups(P=0.14) at 1 wk. Incidence of cells/flare postoperative was statistically not significant(P=0.82) in both groups at all follow up visits. Postoperative macular oedema was not observed at any follow up visit. CONCLUSION: SCTA appears to be an effective alternative to prolong postoperative topical steroid use.