Using selenium-conjugated polyethylene glycol to enhance the stability of gold nanoparticles in biologically relevant samples

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（2）
• 页码范围: 280-286
• 页数: 7页
• 语种: 英文

摘要

Using stabilizing agents to maintain the physicochemical properties of colloids in complex environments is crucial for their realworld applications.In this article,we describe how selenium-(Se-) terminated polyethylene glycol (PEG) can serve as a highaffinity stabilizing agent for gold nanoparticles (AuNPs).Compared to AuNPs modified with standard thiolated PEG (S-PEG),Se-PEG-coated AuNPs are much more stable under extreme conditions such as high/low pH,high salt content,and high temperatures.We demonstrate that the Se anchor can prevent the dissociation of PEG ligands from AuNP surfaces in living cells,where a higher concentration of biothiols is usually present.These results indicate that Se-PEG is an excellent stabilizing agent that may facilitate further studies on metal NPs for various complex and physiological systems.