Limited distribution and mechanism of the TetX4 tetracycline resistance enzyme

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2019,（20）
• 页码范围: 1478-1481
• 页数: 4页
• 语种: 英文

摘要

Tetracyclines,a group of antimicrobial agents targeting protein synthesis,have been extensively used in agricultural,veterinary,and clinic settings [1].The sporadic rise in tetracycline resistance is partially due to the occurrence of efflux pumps and/or ribosome protection [1,2].The growing body of tetracycline-inactivating enzymes (e.g.,TetX (X1 to X4) [3,4] and Tet (47 to 55) [5]) represents an alternative mechanism for tetracycline resistance,and threatens the renewed interest of tigecycline as a last-resort defense against lethal infections with carbapenem-resistant Enter obacteriaceae and Acinetobacter species.