Myasthenia gravis and pregnancy

• 作者: Goun Je Mehdi Ghasemi
• 来源期刊: 世界妇产科杂志
• 学科: 医学
• 关键词: PREGNANCY Myasthenia gravis Delivery POSTPARTUM Transient neonatal myasthenia gravis PYRIDOSTIGMINE
• 年，卷（期）: 2020,（1）
• 页码范围: 1-10
• 页数: 10页
• 分类号: R71

摘要

Myasthenia gravis (MG) is an autoimmune disorder of neuromuscular junctionthat has higher incidence in younger women than men, which could be related todifferences in sex hormones physiology and immune system functioning betweenmales and females. MG can first present during pregnancy and variably affectpregnancy, labor, and postpartum period. In this paper, we had an updatedoverview on our understanding about MG presentation and its effect onpregnancy and vice versa, therapeutic options for MG pregnant women,management of pregnancy or labor complications in MG patients, and finally fetaland neonatal considerations in MG pregnant women. A multidisciplinaryapproach, involving obstetricians/gynecologists, neurologists, and anesthesiologists,plays a pivotal role in improving the clinical outcomes in both MGmothers and their infants during pregnancy, delivery and postpartum.