Complement activation in obesity,insulin resistance,and type 2 diabetes mellitus

• 作者: Catherine Yang Hongbin Wang Kyumin Shim Rayhana Begum
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: Inflammation COMPLEMENT activation Metabolic DISORDERS OBESITY Insulin resistance Type 2 DIABETIC MELLITUS
• 年，卷（期）: 2020,（1）
• 页码范围: 1-12
• 页数: 12页
• 分类号: R58

摘要

Amplified inflammatory reaction has been observed to be involved in cardiometabolic diseases such as obesity,insulin resistance,diabetes,dyslipidemia,and atherosclerosis.The complement system was originally viewed as a supportive first line of defense against microbial invaders,and research over the past decade has come to appreciate that the functions of the complement system extend beyond the defense and elimination of microbes,involving in such diverse processes as clearance of the immune complexes,complementing T and B cell immune functions,tissue regeneration,and metabolism.The focus of this review is to summarize the role of the activation of complement system and the initiation and progression of metabolic disorders including obesity,insulin resistance and diabetes mellitus.In addition,we briefly describe the interaction of the activation of the complement system with diabetic complications such as diabetic retinopathy,nephropathy and neuropathy,highlighting that targeting complement system therapeutics could be one of possible routes to slow down those aforementioned diabetic complications.