Preparation of the Rutin-SBA-16 Drug Delivery System

• 作者: Adriana Pereira Duarte Aline Regina Hellman Carollo Daniel Araujo Gon?alves Gustavo Rocha de Castro Juliana Camila Fischer Karnopp Marco Antonio Utrera Martines Teófilo Fernando Mazon Cardoso
• 来源期刊: 生物材料与纳米技术(英文)
• 学科: 化学
• 关键词: RUTIN CONTROLLED RELEASE Systems KINETIC Study MESOPOROUS SILICA Flavonoid
• 年，卷（期）: swclynmjsyw_2020,（1）
• 页码范围: 1-13
• 页数: 13页
• 分类号: O64

摘要

This study sets out a scheme for a controlled release delivery system using SBA-16 as a carrier matrix and Rutin as a drug (Rutin-SBA-16). Physicochemical characterizations were performed to confirm the structure of the SBA-16 for post-synthesis by scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM) and X-ray Diffraction (XRD). The presence of Rutin-SBA-16 was confirmed by Fourier-transform infrared spectroscopy (FTIR) and Nitrogen adsorption-desorption isotherms at 77 K. The dissolution kinetics was evaluated by the Zero Order, First Order and Higuchi models, and Rutin quantification was carried out by High Performance Liquid Chromatography (HPLC). The best impregnation time, which was 8 hours, adsorbing 284 μg Rutin per mg of silica, and the maximum degree of dissolution occurred in a period of 20 - 25 h. The release kinetics of the Rutin was called Higuchi, and showed high linearity, with a correlation coefficient (R2) of 0.999 compared with 0.905 and 0.980 of the zero order and first order models respectively. The study shows the benefits of Rutin-SBA-16 as a drug delivery system.